The autoinjector delivers lecanemab-irmb in a regimen of two consecutive 250 mg injections, totaling 500 mg weekly for therapy initiation. After 18 months of treatment, patients may transition to a 360 mg maintenance dose. This delivery method is designed to reduce the time burden associated with clinic visits and infusion preparation, potentially streamlining the overall care pathway for patients and their caregivers.

Eisai and Biogen are supporting the rollout with a comprehensive resource package, including a "Welcome Kit" and a digital companion app developed with Medisafe Ltd. to assist with dose tracking and education. While the shift to subcutaneous administration offers significant logistical benefits, the safety profile remains consistent with the intravenous version, including the risk of amyloid-related imaging abnormalities (ARIA). Patients are encouraged to work closely with their healthcare providers to manage monitoring requirements, such as periodic brain MRIs, regardless of whether they choose home-based injections or clinical infusions.